Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
نویسندگان
چکیده
منابع مشابه
Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions.
Human immunodeficiency viruses (HIVs) and the related bovine lentiviruses bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) utilize the viral Tat protein to activate viral transcription. The arginine-rich RNA-binding domains of the Tat proteins bind to their cognate transactivation response element (TAR) RNA hairpins located at the 5' ends of the viral mRNAs, resulting in enh...
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A common rate-limiting step in the transcription of inducible eukaryotic genes is the release of RNA polymerase II (RNAPII) molecules from stalled elongation complexes that accumulate shortly after the initiation of RNA synthesis (Blair et al. 1996; Blau et al. 1996; for review, see Greenblatt et al. 1993; Bentley 1995). In the absence of the inducer protein, transcription at these genes is usu...
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چکیده هدف از این کار بررسی الکترواکسیداسیون کتکول و مشتقات آن در حضور 4-فنیل سمی کاربامازید بوده است اکسیداسیون کتکولها ترکیبات نا پایدار کینونها را تولید می کنند که این ترکیبات می تواند در واکنش مایکل بعنوان پذیرنده نوکلئوفیل عمل نمایند. در ادامه اکسایش کتکولهای (a-c1) را درحضور 4-فنیل سمی کاربامازید در محلول آب/استونیتریل (90/10)بوسیله ولتامتری چرخه ای و کولن متری در پتانسیل ثابت مورد بررسی ...
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ژورنال
عنوان ژورنال: AIDS
سال: 2019
ISSN: 0269-9370
DOI: 10.1097/qad.0000000000002268